UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the Wnt/β-catenin pathway in vitro ovarian culture system.

Wenjuan XuCaiyun WuXiaoqian ZhuJingjing WuZhiguo ZhangZhaolian WeiYunxia CaoPing ZhouJianye Wang

Published in: Stem cell research & therapy (2022)

This in vitro study showed the beneficial effects of UC-MSCs on thawed ovaries and explored a potential mechanism inducing angiogenesis. In particular, 3D ovarian culture system supported by Matrigel further improved UC-MSCs treatment. The in vitro culture system using Matrigel and UC-MSCs may provide a potential treatment strategy for improving the success rate of thawed ovaries transplantation.

Keyphrases

mesenchymal stem cells
umbilical cord
pregnancy outcomes
cell proliferation
vascular endothelial growth factor
pregnant women
combination therapy
risk assessment
cell therapy
bone marrow
wound healing
climate change