CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma.

Xiaomeng LiuRong TangJin XuZhen TanChen LiangQingcai MengYubin LeiJie HuaYiyin ZhangJiang LiuBo ZhangWei WangXianjun YuXianjun Yu

Published in: Gut (2023)

The CRIP1/NF-κB/CXCL axis is critical for triggering immune evasion and TIME formation in PDAC. Blockade of this signalling pathway prevents MDSC trafficking and thereby sensitises PDAC to immunotherapy.

Keyphrases

signaling pathway
lps induced
pi k akt
nuclear factor
oxidative stress
stem cells
inflammatory response
mouse model
toll like receptor
cell proliferation