Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452.

Barend W FlorijnJacques M G J DuijsMaartje KlaverEline N KuipersSander KooijmanJurrien PrinsHuayu ZhangHetty C M SipsWendy StamMaaike HanegraafRonald W A L LimpensRienk NieuwlandBas B van RijnTon J RabelinkPatrick C N RensenMartin den HeijerRoel BijkerkAnton Jan van Zonneveld

Published in: European journal of endocrinology (2021)

This study identified an estradiol-drive post-transcriptional network that could potentially offer a mechanistic understanding of metabolism following gender-affirming estradiol therapy.

Keyphrases

estrogen receptor
gene expression
transcription factor
mental health
oxidative stress
smoking cessation