Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities.

Kelly FraserVamsi KodaliNaveena YanamalaM Eileen BirchLorenzo CenaGary CasuccioKristin BunkerTraci L LerschDouglas E EvansAleksandr StefaniakMary Ann HammerMichael L KashonTheresa BootsTracy EyeJohn HubczakSherri A FriendMatthew DahmMary K Schubauer-BeriganKatelyn SiegristDavid LowryAlison K BauerLinda M SargentAaron Erdely

Published in: Particle and fibre toxicology (2020)

Distributions of physical dimensions provided more consistent grouping of CNT/F with respect to toxicity outcomes compared to means only. All CNT/F induced some level of genotoxicity in human epithelial cells. The severity of toxicity was dependent on the sample containing a proportion of tubes with greater nominal lengths and diameters.

Keyphrases

carbon nanotubes
oxide nanoparticles
endothelial cells
high glucose
oxidative stress
diabetic rats
physical activity
induced pluripotent stem cells
drug induced