In silico, anti-inflammatory and acute toxicological evaluation of an indigenous medicinal plant Pterospermum rubiginosum using Sprague-Dawley rats.

Rajamohanan Jalaja AnishAswathy NairV SaraswathyVelappan Nair S KalpanaRajendran L Shyma

Published in: Laboratory animal research (2024)

PRME administration significantly downregulated the gene expression of inflammatory markers, such as iNOS, IL-6, and IL-10. The molecular docking analysis of iNOS and IL-6 supports the in vitro study. In vivo toxicological study of PRME in SD rats was found to be non-toxic up to a concentration of 1000 mg/kg body weight for 14 days.

Keyphrases

molecular docking
gene expression
body weight
anti inflammatory
molecular dynamics simulations
dna methylation
liver failure
intensive care unit
hepatitis b virus