Accumulation of uraemic toxins is reflected only partially by estimated GFR in paediatric patients with chronic kidney disease.

Snauwaert EvelienWim Van BiesenAnn RaesEls HolvoetGriet GlorieuxKoen Van HoeckMaria Van DyckNathalie GodefroidRaymond VanholderSanne RoelsJohan Vande WalleSunny Eloot

Published in: Pediatric nephrology (Berlin, Germany) (2017)

This study demonstrates that eGFR poorly predicts concentrations of protein-bound uraemic toxins, UA and ADMA in childhood CKD. Therefore, eGFR only partially reflects the complexity of the accumulation pattern of uraemic toxins in childhood CKD.

Keyphrases

small cell lung cancer
chronic kidney disease
epidermal growth factor receptor
tyrosine kinase
early life
emergency department
intensive care unit
childhood cancer
young adults