Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia.

Shanshan LuYiwei LiQiang ShenWanli ZhangXiaofan GuMingliang MaYiming LiLiuqiang ZhangXuan Liu Xiong-Wen Zhang

Published in: Journal of cachexia, sarcopenia and muscle (2021)

CS and its analogues exhibited anticachexia effects mainly by inhibiting TNF-α/NF-κB pathway and decreasing muscle and adipose tissue loss. CS and its analogues might be promising drug candidates for the treatment of cancer cachexia.

Keyphrases

adipose tissue
papillary thyroid
molecular docking
signaling pathway
squamous cell
skeletal muscle
insulin resistance
structure activity relationship
rheumatoid arthritis
lymph node metastasis
lps induced
type diabetes
metabolic syndrome
pi k akt
childhood cancer
drug induced
adverse drug
replacement therapy