Arsenic Exposure and Epigenetic Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study.

Enoch X JiangArce Domingo-RellosoAhlam AbuawadKarin HaackMaria Tellez-PlazaM Danielle FallinJason G UmansLyle G BestYing ZhangAllison KupscoDaniel W BelskyShelley A ColeAna Navas-Acien

Published in: Environmental health perspectives (2023)

Arsenic exposure was associated with older GrimAge and faster DunedinPACE measures of biological age. Furthermore, accelerated biological aging measured from DNA methylation accounted for a relevant fraction of As-associated risk for CVD, CVD mortality, and all-cause mortality in the SHS, supporting the role of As in accelerated aging. Research of the biological underpinnings can contribute to a better understanding of the role of aging in arsenic-related disease. https://doi.org/10.1289/EHP11981.

Keyphrases

dna methylation
cardiovascular disease
drinking water
heavy metals
gene expression
cardiovascular events
genome wide
type diabetes
risk assessment
middle aged
copy number