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Arsenic Exposure and Epigenetic Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study.

Enoch X JiangArce Domingo-RellosoAhlam AbuawadKarin HaackMaria Tellez-PlazaM Danielle FallinJason G UmansLyle G BestYing ZhangAllison KupscoDaniel W BelskyShelley A ColeAna Navas-Acien
Published in: Environmental health perspectives (2023)
Arsenic exposure was associated with older GrimAge and faster DunedinPACE measures of biological age. Furthermore, accelerated biological aging measured from DNA methylation accounted for a relevant fraction of As-associated risk for CVD, CVD mortality, and all-cause mortality in the SHS, supporting the role of As in accelerated aging. Research of the biological underpinnings can contribute to a better understanding of the role of aging in arsenic-related disease. https://doi.org/10.1289/EHP11981.
Keyphrases
  • dna methylation
  • cardiovascular disease
  • drinking water
  • heavy metals
  • gene expression
  • cardiovascular events
  • genome wide
  • type diabetes
  • risk assessment
  • middle aged
  • copy number