Overnight fasting before lapatinib administration to breast cancer patients leads to reduced toxicity compared with nighttime dosing: a retrospective cohort study from a randomized clinical trial.

Moe TsudaHiroshi IshiguroNaoko ToriguchiNorikazu MasudaHiroko BandoMasahiro OhgamiMasato HommaSatoshi MoritaNaohito YamamotoKatsumasa KuroiYasuhiro YanagitaToshimi TakanoSatoru ShimizuMasakazu Toi

Published in: Cancer medicine (2020)

Compared to bedtime administration, lapatinib administration after overnight fasting reduces its toxicity without diminishing its therapeutic efficacy.

Keyphrases

blood glucose
oxidative stress
insulin resistance
positive breast cancer
skeletal muscle