High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader-blinded study with potential clinical implications.
Maura CorsettiAlexander ThysAlexander HarrisGiuseppe PagliaroEveline DelooseIngrid DemedtsTack JanPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
In humans, PEG, prucalopride, and bisacodyl have distinct effects on colonic motility. This information has clinical implication, as it indicates that the combination of prucalopride and bisacodyl, normally not considered in clinical practice, could be effective in treating patients with constipation refractory to single medications.
Keyphrases
- open label
- placebo controlled
- high resolution
- phase iii
- double blind
- phase ii
- clinical practice
- study protocol
- clinical trial
- phase ii study
- biofilm formation
- liver failure
- ulcerative colitis
- respiratory failure
- healthcare
- pseudomonas aeruginosa
- squamous cell carcinoma
- irritable bowel syndrome
- tandem mass spectrometry
- escherichia coli
- human health
- hepatitis b virus
- extracorporeal membrane oxygenation