Population Pharmacokinetics of Unbound and Total Teicoplanin in Critically Ill Pediatric Patients.
L B S AulinP De PaepeE DhontA de JaegerJ Vande WalleW VandenbergheB C McWhinneyJ P J UngererJ G C van HasseltPieter A J G de CockPublished in: Clinical pharmacokinetics (2020)
We successfully characterized the pharmacokinetics of unbound and total teicoplanin in critically ill pediatric patients. The highly variable unbound fraction of teicoplanin could not be predicted using albumin levels, which may support the use of therapeutic drug monitoring of unbound concentrations. Poor target attainment was shown for the most commonly used dosing regimen, regardless of the pharmacokinetic-pharmacodynamic target evaluated.
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