Endocardial HDAC3 is required for myocardial trabeculation.

Jihyun JangMette Bentsen Ye-Jun KimErick KimVidu GargChen-Leng CaiMario LoosoDeqiang Li

Published in: bioRxiv : the preprint server for biology (2023)

Our findings reveal a critical signaling pathway in which endocardial HDAC3 promotes trabecular myocardium growth by stimulating TGFß signaling through repressing miR-129-5p, providing novel insights into the etiology of congenital heart disease and conceptual strategies to promote myocardial regeneration.

Keyphrases

congenital heart disease
left ventricular
signaling pathway
histone deacetylase
cardiac resynchronization therapy
stem cells
pi k akt
epithelial mesenchymal transition
single cell
oxidative stress
wound healing
endoplasmic reticulum stress
bone loss