Membrane RRM2-positive cells represent a malignant population with cancer stem cell features in intrahepatic cholangiocarcinoma.

Yongzhi ZhaoShuting XueDanduo WeiJianjuan ZhangNachuan ZhangLiping MaoNiya LiuLei ZhaoJianing YanYifan WangXiujun CaiSaiyong ZhuStephanie RoesslerJunfang Ji

Published in: Journal of experimental & clinical cancer research : CR (2024)

RRM2 had an alternative cell membrane localization. The membrane RRM2-positive iCCA cells represented a malignant subpopulation with cancer stem cell features.

Keyphrases

cancer stem cells
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
pi k akt