An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.
Zhipei LiuFeng WangHui YuanFuyun TianChuanyan YangFei HuYiyao LiuMeiqin TangMeixuan PingChunlan KangTing LuoGuimei YangMei HuZhaobing GaoPing LiPublished in: BMC biology (2024)
Our data provide evidence that a potential cooperation mechanism in the extracellular vestibule of the VSD and the PD would determine the gating polarity in hERG.