A framework for voxel-based assessment of biological effect after proton radiotherapy in pediatric brain cancer patients using multi-modal imaging.

Mikkel SkaarupMichael Juncker LundemannSune DarknerMorten JørgensenLisbeth MarnerDragan MirkovicDavid GrosshansChristopher PeelerRadhe MohanIvan Richter VogeliusAne Appelt

Published in: Medical physics (2021)

The imaging changes could successfully model biological effect as a function of dose and LET using our proposed framework. Due to the low number of patients, the imaging changes observed for FA and T2 scans were not marked enough to draw any firm conclusions.

Keyphrases

high resolution
ejection fraction
early stage
newly diagnosed
prognostic factors
multiple sclerosis
mass spectrometry
fluorescence imaging
patient reported outcomes
peritoneal dialysis
cerebral ischemia
childhood cancer