Insulin-like growth factor axis in pregnancies affected by fetal growth disorders.

Aamod R NawatheMark ChristianSung Hye KimMark JohnsonMakrina D SavvidouVasso Terzidou

Published in: Clinical epigenetics (2016)

Our results suggest that changes in CpG methylation contribute to the changes in gene expression of components of the IGF axis in fetal growth disorders. Differential methylation of the IGF1 gene and its binding proteins is likely to play a role in the pathogenesis of SGA neonates.

Keyphrases

dna methylation
gene expression
genome wide
growth hormone
binding protein
transcription factor