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Insulin-like growth factor axis in pregnancies affected by fetal growth disorders.

Aamod R NawatheMark ChristianSung Hye KimMark JohnsonMakrina D SavvidouVasso Terzidou
Published in: Clinical epigenetics (2016)
Our results suggest that changes in CpG methylation contribute to the changes in gene expression of components of the IGF axis in fetal growth disorders. Differential methylation of the IGF1 gene and its binding proteins is likely to play a role in the pathogenesis of SGA neonates.
Keyphrases
  • dna methylation
  • gene expression
  • genome wide
  • growth hormone
  • binding protein
  • transcription factor