Mast Cells Promote Nonalcoholic Fatty Liver Disease Phenotypes and Microvesicular Steatosis in Mice Fed a Western Diet.

Lindsey KennedyVik MeadowsAmelia SybengaJennifer DemievilleLixian ChenLaura HargroveBurcin EkserWasim DarLudovica CeciDebjyoti KunduKonstantina KyritsiLinh PhamTianhao ZhouShannon GlaserFanyin MengGianfranco AlpiniHeather Francis

Published in: Hepatology (Baltimore, Md.) (2021)

MCs promote WD-induced biliary and liver damage and may promote microvesicular steatosis development during NAFLD progression to NASH through miR-144-3p/ALDH1A3 signaling. Inhibition of MC activation may be a therapeutic option for NAFLD/NASH treatment.

Keyphrases

high fat diet induced
insulin resistance
high fat diet
physical activity
high glucose
oxidative stress
south africa
metabolic syndrome
drug induced
skeletal muscle
endothelial cells
liver fibrosis
smoking cessation