Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.
Carolin HellerMartha S FoianiKatrina M MooreRhian S ConveryMartina BocchettaMollie NeasonDavid M CashDavid L ThomasCaroline V GreavesIone O C WoollacottRachelle ShafeiJohn Cornelis van SwietenFermin MorenoRaquel Sanchez-ValleBarbara BorroniRobert LaforceMario MasellisMaria Carmela TartagliaCaroline GraffDaniela GalimbertiJames Benedict RoweElizabeth C FingerMatthis SynofzikRik VandenbergheAlexandre de MendoncaFabrizio TagliaviniIsabel SantanaSimon DucharmeChristopher R ButlerAlex GerhardJohannes LevinAdrian DanekGiovanni FrisoniSandro SorbiMarkus OttoAmanda J HeslegraveHenrik ZetterbergJonathan Daniel Rohrernull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
Raised GFAP concentrations appear to be unique to GRN-related FTD, with levels potentially increasing just prior to symptom onset, suggesting that GFAP may be an important marker of proximity to onset, and helpful for forthcoming therapeutic prevention trials.