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Rare myxoid pleomorphic liposarcoma: a case report and literature review.

Yanying ShenLing ZhaoAnqi LiQi PengQiang LiuLisha WangZebing Liu
Published in: Journal of clinical pathology (2024)
We report a case of a middle-aged woman with a rapidly growing abdominal mass that was diagnosed as myxoid pleomorphic liposarcoma, a recently recognised, rare and aggressive subtype of liposarcoma. The tumour exhibits a combination of histological features from both myxoid liposarcoma and pleomorphic liposarcoma. Genetic analysis revealed mutations in TP53 and RB1, along with widespread loss of heterozygosity. However, no DDIT3 gene translocation or MDM2/CDK4 gene amplification was detected. These genetic characteristics can be used to distinguish this type of liposarcoma from others. Two unusual gene fusion/rearrangements, CREB5::TERT fusion and ETV1::LFNG rearrangement, were identified. The patient underwent complete removal of the tumour without the use of radiotherapy or chemotherapy. No recurrence was observed during the follow-up period of 18 months.
Keyphrases
  • genome wide
  • copy number
  • middle aged
  • locally advanced
  • case report
  • early stage
  • acute lymphoblastic leukemia
  • radiation therapy
  • cell cycle
  • single cell
  • gene expression
  • genome wide analysis