Dietary pectin and inulin: A promising adjuvant supplement for collagen-induced arthritis through gut microbiome restoration and CD4 + T cell reconstitution.
Yu LouXianghui WenSiyue SongYufeng ZengLin HuangZhijun XieTiejuan ShaoChengping WenPublished in: The Journal of nutritional biochemistry (2024)
Dietary strategies rich in fiber have been demonstrated to offer benefits to individuals afflicted with rheumatoid arthritis (RA). However, the specific mechanisms through which a high-fiber diet (HFD) mitigates RA's autoimmunity remain elusive. Herein, we investigate the influence of pectin- and inulin-rich HFD on collagen-induced arthritis (CIA). We establish that HFD significantly alleviates arthritis in CIA mice by regulating the Th17/Treg balance. The rectification of aberrant T cell differentiation by the HFD is linked to the modulation of gut microbiota, augmenting the abundance of butyrate in feces. Concurrently, adding butyrate to the drinking water mirrors the HFD's impact on ameliorating CIA, encompassing arthritis mitigation, regulating intestinal barrier integrity, and restoring the Th17/Treg equilibrium. Butyrate reshapes the metabolic profile of CD4 + T cells in an AMPK-dependent manner. Our research underscores the importance of dietary interventions in rectifying gut microbiota for RA management and offers an explanation of how diet-derived microbial metabolites influence RA's immune-inflammatory-reaction.
Keyphrases
- rheumatoid arthritis
- high fat diet
- drinking water
- disease activity
- ankylosing spondylitis
- physical activity
- high glucose
- interstitial lung disease
- adipose tissue
- insulin resistance
- diabetic rats
- weight loss
- oxidative stress
- drug induced
- early stage
- skeletal muscle
- molecular dynamics
- climate change
- health risk assessment
- type diabetes
- ms ms
- tissue engineering
- molecular dynamics simulations
- systemic lupus erythematosus
- metabolic syndrome
- endothelial cells
- risk assessment
- mouse model
- stress induced
- celiac disease