Vorinostat, temozolomide or bevacizumab with irradiation and maintenance BEV/TMZ in pediatric high-grade glioma: A Children's Oncology Group Study.
Rishi R LullaAllen BuxtonMark D KrailoMargot A LazowDaniel R BoueJames L LeachTong LinJames I GellerShiva Senthil KumarMarina N NikiforovaUma ChandranSachin S JogalMarvin D NelsonArzu Onar-ThomasDaphne A Haas-KoganKenneth J CohenMark W KieranAmar GajjarRachid DrissiIan F PollackMaryam FouladiPublished in: Neuro-oncology advances (2024)
Chemoradiotherapy with vorinostat or bevacizumab is not superior to temozolomide in children with newly diagnosed HGG. Patients with telomerase- and ALT-negative tumors had higher EFS suggesting that, if reproduced, mechanism of telomere maintenance should be considered in molecular-risk stratification in future studies.