Induction of a Single-Dose of Streptozotocin (50 Mg) in Rat Model Causes Insulin Resistance with Type 2 Diabetes Mellitus.

Mridula SharmaHor Kuan ChanCharlie A LavillaMylene M UyGabriele Ruth Anisah FroemmingOkechukwu Patrick Nwabueze

Published in: Fundamental & clinical pharmacology (2023)

Biochemical investigation indicates that STZ can generate diabetes complications through hepatocellular damage, elevated HbA1c, kidney damage, hyperlipidemia, cardiovascular damage, and impairment of the insulin signaling pathway.

Keyphrases

type diabetes
high fat diet
oxidative stress
insulin resistance
diabetic rats
signaling pathway
glycemic control
cardiovascular disease
adipose tissue
pi k akt
metabolic syndrome
risk factors
skeletal muscle
high fat diet induced
induced apoptosis
polycystic ovary syndrome
weight loss