Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment.

Tristan CourauJulie BonnereauJustine ChicoteauHugo BottoisRomain RemarkLaura Assante MirandaAntoine ToubertMathieu BleryThomas AparicioMatthieu AllezLionel Le Bourhis

Published in: Journal for immunotherapy of cancer (2019)

Altogether, we show that tumor spheroids represent a relevant tool to study tumor-lymphocyte interactions on human tissues and revealed the antitumor potential of immunomodulatory antibodies targeting MICA/B and NKG2A.

Keyphrases

endothelial cells
cancer therapy
gene expression
single cell
natural killer cells
drug delivery
climate change