Riparin II-type benzamides as novel antibiofilm agents against dermatophytes: chemical synthesis, in vitro, ex vivo and in silico evaluation.

Marcelo Antônio Nóbrega da RochaEmanuel Pereira SilvaRisley Nikael Medeiros SilvaGabriela Ribeiro de SousaJosé Maria Barbosa-FilhoMayara Dos Santos MaiaAlberto Shellygton LimaJailton de Souza-FerrariFillipe de Oliveira Pereira

Published in: The Journal of antimicrobial chemotherapy (2024)

Our study shows the antibiofilm potential for riparin II-type benzamides as new drugs targeting dermatophytes by inhibiting the Ssu1 protein.

Keyphrases

cancer therapy
binding protein
risk assessment
amino acid
human health
small molecule