Impinging flow mediates vascular endothelial cell injury through the PKCα/ERK/PPARγ pathway in vitro.
Zelong XingZheng HaoYanyang ZengJiacong TanZhixiong ZhangYeyu ZhaoHuaxin ZhuMeihua Li
Published in: Cerebrovascular diseases (Basel, Switzerland) (2024)
Our findings suggest that the PKCα/ERK/PPARγ pathway plays a crucial role in mediating endothelial injury under conditions of impinging flow, with potential implications for vascular diseases and intracranial aneurysm development.