Chiral Macroporous MOF Surfaces for Electroassisted Enantioselective Adsorption and Separation.

The development of surfaces with chiral features is a fascinating challenge for modern materials science, especially when they are used for chiral separation technologies. In this contribution, the design of hierarchically structured chiral macroporous zeolitic imidazolate framework-8 (ZIF-8) electrodes is presented. They are elaborated by an electrochemical deposition-dissolution technique based on the electrodeposition of metal through a colloidal crystal template, followed by controlled electrooxidation. This generates locally metal cations, which can interact with a chiral ligand present in the solution to form metal-organic frameworks (MOFs). The macroporous structure facilitates the access of the chiral recognition sites, located in the mesoporous MOF, and thus helps to overcome mass transport limitations. The efficiency of the designed functional materials for chiral adsorption and separation can be fine-tuned by applying an adjustable electric potential to the electrode surfaces. This hierarchical chiral ZIF-8 structure was deposited at the walls of a microfluidic device and used as a stationary phase for enantioselective separation. The potential-controlled interaction between the stationary phase and the chiral analytes allows baseline separation of two enantiomers. This opens up interesting perspectives for using hierarchically structured chiral MOFs as an efficient material for the selective adsorption and separation of chiral compounds.