ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas.
Wenjia WangScott C FriedlandBing GuoMichael R O'DellWilliam B AlexanderChrista L Whitney-MillerDiana Agostini-VulajAaron R HuberJason R MyersJohn M AshtonRichard F DunneLaurie A SteinerAram F HezelPublished in: Gut (2018)
ARID1A plays a key role in pancreatic acinar homeostasis and response to injury. Furthermore, ARID1A restrains oncogenic KRAS-driven formation of premalignant proliferative IPMN. Arid1a-deficient PDACs are poorly differentiated and have mesenchymal features conferring migratory/invasive and stem-like properties.