GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase.

Mikio OkayamaKota FujimoriMariko SatoKoichi SamataKoki KuritaHiromu SugiyamaYutaka SutoGenji IwasakiTaketo YamadaFumiyuki KiuchiDaiju IchikawaMaiko MatsushitaMaki HiraoHisako KuniedaKohei Yamazaki Yutaka Hattori

Published in: Cancer medicine (2023)

Natural products or and their derivatives can could be good sources of antineoplastic drugs even for high-risk cancer.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
induced apoptosis
papillary thyroid
high glucose
diabetic rats
multiple myeloma
endoplasmic reticulum stress
signaling pathway
squamous cell carcinoma
oxidative stress
endothelial cells
newly diagnosed
cell proliferation
childhood cancer
water soluble