Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study.
Daan van KruiningMario LosenSimone M CrivelliJoost J A de JongJacobus F A JansenWalter H BackesJennifer Monereo-SánchezMartin P J van BoxtelSebastian KöhlerDavid E J LindenMiranda T SchramMichelle M MielkePilar Martinez-MartinezPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2023)
Our results warrant further analysis of plasma ceramides as potential markers for MCI in middle-aged men. In contrast to previous studies, no associations of plasma sphingolipids with MCI or brain volumes were found in women, independent of age. These results highlight the importance of accounting for sex- and age-related factors when examining sphingolipid and CERT metabolism related to cognitive function.