M1 macrophages involved in the pathogenesis of placental chronic villitis of unknown etiology.

João Figueira ScariniNatália de Magalhães RodriguesWellington Lima SabinoCiro Dantas SoaresThayná Melo de Lima MoraisReydson Alcides de Lima SouzaLívia Ramalho CrescencioRogério de Oliveira Gondak Fernanda Viviane MarianoAlbina AltemaniFernanda Viviane Mariano

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)

We conclude that the almost exclusive presence of M1 macrophages in the inflamed areas suggests the influence of these cells in the pathogenesis VUE. The greater amount of M2 in villitis and normal areas suggests a possible immunoregulatory mechanism of the inflammatory process in VUE.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
signaling pathway
pi k akt