Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal.
Joseph W JacksonJames S FosterEmily B MartinSallie MacyCraig WooliverManasi BalachandranTina RicheyR Eric HeidelAngela D WilliamsStephen J KennelJonathan S WallPublished in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)
These data suggest that amyloid-associated collagen serves as a 'don't eat me' signal, thereby hindering clearance of amyloid. Targeted degradation of amyloid-associated collagen could result in innate immune cell recognition and clearance of pathologic amyloid deposits.