Statins decrease overall mortality and cancer related mortality but are underutilized in NAFLD: a longitudinal analysis of 12,538 individuals.
Cheng-Han NgMargaret Lp TengNicholas W S ChewKai En ChanJie Ning YongJingxuan QuekDarren Jun Hao TanWen Hui LimGabriel Sheng Jie LeeJessica WongApichat KaewdechDaniel Q HuangJiongwei WangMark Yan-Yee ChanMazen NoureddinMohammad Shadab SiddiquiArun SanyalMark MuthiahPublished in: Expert review of gastroenterology & hepatology (2022)
Over concerns of hepatotoxicity and lack of evidence in reducing mortality events, statins remain underutilized in NAFLD. However, statin use was associated with a significant reduction in overall and cancer-related mortality. The lack of reduction in cardiovascular disease mortality is likely a selection bias of patients, where individuals with higher risk are more likely to receive treatment.