White matter changes in chronic and episodic migraine: a diffusion tensor imaging study.
Álvaro Planchuelo-GómezDavid García-AzorínÁngel Luis Guerrero-PeralSantiago Aja-FernándezMargarita RodríguezRodrigo de Luis-GarcíaPublished in: The journal of headache and pain (2020)
These findings suggest global white matter structural differences between episodic migraine and chronic migraine. Patients with chronic migraine could present axonal integrity impairment in the first months of chronic migraine with respect to episodic migraine patients. White matter changes after the onset of chronic migraine might reflect a set of maladaptive plastic changes.