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Impaired immunity and high attack rates caused by SARS-CoV-2 variants among vaccinated long-term care facility residents.

Dorothée ObachAnna SolastieOona LiedesSaimi VaraEva Krzyżewska-DudekLuise BrinkmannAnu HaveriCharlotte C HammerTimothée DubSeppo K MeriTobias L FreitagOuti LyytikäinenMerit Melin
Published in: Immunity, inflammation and disease (2022)
The vaccinated elderly remain susceptible to breakthrough infections caused by Alpha and Beta variants. The weaker vaccine response in the elderly needs to be addressed in vaccination protocols, while new variants capable of evading vaccine-induced immunity continue to emerge.
Keyphrases
  • long term care
  • copy number
  • sars cov
  • middle aged
  • high glucose
  • diabetic rats
  • respiratory syndrome coronavirus
  • gene expression
  • endothelial cells
  • oxidative stress
  • coronavirus disease
  • stress induced