Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration.

Andrea Perra Marta Anna Kowalik Lavinia Cabras Massimiliano Runfola Simona Sestito Cristina Migliore Silvia Giordano Grazia Chiellini Simona Rapposelli Amedeo Columbano

Published in: Cell proliferation (2020)

The present study shows that TG68 and IS25 induce massive hepatocyte proliferation without overt toxicity. Hence, these agents may have a significant clinical application for regenerative therapies in liver transplantation or other surgical settings.

Keyphrases

stem cells
mesenchymal stem cells
signaling pathway
cell therapy
liver injury
drug induced