Isolation of Scalimides A-L: β -Alanine-Bearing Scalarane Analogs from the Marine Sponge Spongia sp.
A-Young ShinHyi-Seung LeeJihoon LeePublished in: Marine drugs (2022)
A chemical investigation of a methanol extract of Spongia sp., a marine sponge collected from the Philippines, identified 12 unreported scalarane-type alkaloids-scalimides A-L ( 1 - 12 )-together with two previously described scalarin derivatives. The elucidation of the structure of the scalaranes based on the interpretation of their NMR and HRMS data revealed that 1 - 12 featured a β -alanine-substituted E-ring but differed from each other through variations in their oxidation states and substitutions occurring at C16, C24, and C25. Evaluation of the antimicrobial activity of 1 - 12 against several Gram-positive and Gram-negative bacteria showed that 10 and 11 were active against Micrococcus luteus and Bacillus subtilis, respectively, with MIC values ranging from 4 to 16 μg/mL.
Keyphrases
- bacillus subtilis
- molecular docking
- magnetic resonance
- gram negative
- oxidative stress
- high resolution
- electronic health record
- big data
- hydrogen peroxide
- high resolution mass spectrometry
- solid state
- anti inflammatory
- carbon dioxide
- mass spectrometry
- data analysis
- machine learning
- deep learning
- liquid chromatography
- structure activity relationship
- visible light