An ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry method based on a four-step analysis strategy to investigate metabolites of Qi-Yu-San-Long decoction in rat plasma.
Yue ZhaoYang ChenRuijuan LiTing ZhengMengwen HuangYating GaoZegeng LiHuan WuPublished in: Rapid communications in mass spectrometry : RCM (2022)
In rat plasma, 101 xenobiotics of QYSLD were identified and their dynamic metabolic profiles were systematically delineated, which laid a material basis for further research of the pharmacodynamic substances of QYSLD inhibiting NSCLC.
Keyphrases
- tandem mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- mass spectrometry
- high performance liquid chromatography
- high resolution mass spectrometry
- gas chromatography
- simultaneous determination
- high resolution
- solid phase extraction
- small cell lung cancer
- signaling pathway
- ms ms
- drinking water
- advanced non small cell lung cancer
- epidermal growth factor receptor