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Functional Peptides from SARS-CoV-2 Binding with Cell Membrane: From Molecular Dynamics Simulations to Cell Demonstration.

Yun HaoRongrong WuFenghua WangLiwei ZhangZengkai WangXiaolu SongLei Liu
Published in: Cells (2022)
Herein, we have verified the interaction between the functional peptides from the SARS-CoV-2 and cell membrane, and we further proved that peptides exhibit little membrane disruption. The specific amino acids (Lys, Ile, Glu, Asn, Gln, etc.) with charge or hydrophobic residues play a significant role during the functional-peptide binding to membrane. The findings could provide the hints related to viral infection and also might pave the way for development of new materials based on peptides with membrane-binding activity, which would enable functional peptides further as peptide adjuvants, in order to help deliver the cancer drug into tumor cells for the efficient tumor therapy.
Keyphrases
  • sars cov
  • amino acid
  • molecular dynamics simulations
  • respiratory syndrome coronavirus
  • emergency department
  • papillary thyroid
  • binding protein
  • electronic health record