The aims of the present study were as follows: (1) Using a large sample of adults, estimate overlap between social-relational exposures measured at midlife and well-being measured at midlife and approximately 9-years later. (2) Using a subsample of twins, test for heritable variation in social-relational exposures, and (3) controlling for heritable and shared environmental variation, estimate overlap between social-relational exposures and well-being, both concurrently and approximately 9-years later. Results indicated small-to-moderate overlap between exposures and well-being (mean r = .29, range = .05 to .54). There was also evidence for heritable variation in exposures, and after accounting for these genetic factors, the degree of overlap between social-relational exposures and well-being decreased (mean r = .09, range = -.07 to .33).