The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells.

Felix UlbrichKai B KaufmannAlexander MeskeWolf A LagrèzeMichael AugustynikHartmut BuerkleCarlos C RamaoJulia BiermannUlrich Goebel

Published in: PloS one (2016)

In this study, ALF-186 mediated substantial neuroprotection, affecting intracellular apoptotic signaling, mainly via MAPK p38. CORMs may thus represent a promising therapeutic alternative treating neuronal IRI.

Keyphrases

cerebral ischemia
cell death
cell cycle arrest
induced apoptosis
signaling pathway
anti inflammatory
oxidative stress
subarachnoid hemorrhage
heart failure
endoplasmic reticulum stress
cell proliferation
acute ischemic stroke
coronary artery disease
left ventricular