Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway.

Na LiuDejie FuJunjun YangPingju LiuXiongbo SongXin WangRui LiZhenlan FuJiajia ChenXiaoyuan GongCheng ChenLiu Yang

Published in: Arthritis research & therapy (2020)

AA treatment could reduce hypertrophic and fibrotic differentiation and maintain the chondrogenic phenotype of articular chondrocytes by targeting the AMPK/PI3K/AKT signaling pathway. Our study suggested that AA might be a prospective drug component that targets hypertrophic and fibrotic chondrocytes for OA treatment.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
epithelial mesenchymal transition
systemic sclerosis
induced apoptosis
idiopathic pulmonary fibrosis
mesenchymal stem cells
emergency department
extracellular matrix
bone marrow
knee osteoarthritis
protein kinase