Comprehensive genomic and transcriptomic characterization of high-grade gastro-entero-pancreatic neoplasms.

Valentina AngerilliGiovanna SabellaMichele SimboloVincenzo LaganoGiovanni CentonzeMarco GentiliAlessandro MangognaJorgelina CoppaGiada MunariGianluca BusinelloChiara BorgaFrancesca SchiaviSara PuscedduRita LeporatiSimone OldaniAngelo Paolo Dei Tos Massimo Milione

Published in: British journal of cancer (2024)

This study showed that GEP-NET G3 and GEP-NECs exhibit clear genomic and transcriptomic differences, differently from GEP-NECs <55% and GEP-NECs ≥55%, and provided molecular findings with prognostic and potentially predictive value.

Keyphrases

high grade
single cell
copy number
rna seq
low grade
dna methylation
genome wide