Features and outcomes of patients admitted to the ICU for chimeric antigen receptor T cell-related toxicity: a French multicentre cohort.
Corentin Le CacheuxAudrey CouturierClara SortaisRoch HouotMorgane PéréThomas GastinneAmélie SeguinJean ReignierJean-Baptiste LascarrouJean-Marc TadiéQuentin QuelvenEmmanuel CanetPublished in: Annals of intensive care (2024)
ICU admission is common after CAR-T therapy and is usually performed to manage specific toxicities. Our experience is encouraging, with low ICU mortality despite a high rate of grade 3-4 toxicities, and half of patients being alive and in complete remission at one year.
Keyphrases
- intensive care unit
- end stage renal disease
- mechanical ventilation
- chronic kidney disease
- newly diagnosed
- emergency department
- clinical trial
- prognostic factors
- cardiovascular events
- rheumatoid arthritis
- stem cells
- type diabetes
- disease activity
- adipose tissue
- skeletal muscle
- mesenchymal stem cells
- ulcerative colitis
- cell therapy
- patient reported
- glycemic control