Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome.
Antonis AsiminasSam A BookerOwen R DandoZrinko KozicDaisy ArkellFelicity H InkpenAnna SumeraIrem AkyelPeter C KindEmma R WoodPublished in: Molecular autism (2022)
rats show similar spatial firing properties as those from WT rats but do not show the same experience-dependent increase in spatial specificity or the experience-dependent changes in network coordination. Our findings offer support to a network-level origin of cognitive deficits in FXS.
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