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Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

Deepak Kumar DeepRuchi SinghVasundhra BhandariAditya VermaVanila SharmaSaima WajidShyam SundarV RameshJean Claude DujardinPoonam Salotra
Published in: PLoS neglected tropical diseases (2017)
The present study highlights the parasitic factors and pathways responsible for miltefosine unresponsiveness in VL and PKDL.
Keyphrases
  • oxidative stress
  • dna damage
  • ischemia reperfusion injury
  • emergency department
  • signaling pathway
  • induced apoptosis
  • adverse drug
  • endoplasmic reticulum stress
  • electronic health record