First Report of blaIMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131.
Nicole E StoesserAnna E SheppardGisele PeiranoRobert P SebraTarah LynchLuke W AnsonAndrew KasarskisMary R MotylDerrick W CrookJohann D PitoutPublished in: Antimicrobial agents and chemotherapy (2016)
The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.
Keyphrases
- escherichia coli
- acinetobacter baumannii
- klebsiella pneumoniae
- pseudomonas aeruginosa
- biofilm formation
- genome wide
- single cell
- genome wide identification
- multidrug resistant
- cystic fibrosis
- public health
- drug resistant
- crispr cas
- gram negative
- dna methylation
- genome wide analysis
- staphylococcus aureus
- climate change
- human health