Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury.

Siyi LiuGe LinQiao YangPenghui WangChao MaXiaowei QianXiaomei HeZhangji DongYan LiuMei LiuRonghua WuLiu Yang

Published in: CNS neuroscience & therapeutics (2022)

These results indicate that SASH1 acts as an astrocytic differentiation-maintaining protein, and SASH1 downregulation limits glial activation and contributes toward functional recovery after SCI.

Keyphrases

spinal cord injury
neuropathic pain
spinal cord
signaling pathway
copy number
genome wide identification
dna methylation
small molecule