Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury.

Karim M SaadÉvila Lopes SallesSahar Emami NaeiniBabak BabanMarwa E AbdelmageedRania R AbdelazizGhada M SuddekAhmed A Elmarakby

Published in: Pharmacological reports : PR (2024)

Our findings suggest a differential gender response to UUO-induced kidney injury with males being more sensitive to UUO-induced kidney inflammation, fibrosis, and apoptosis than age-matched females. Importantly, PCA treatment reduced UUO-induced kidney injury in a sex-independent manner which might be attributed to its anti-oxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic properties.

Keyphrases

high glucose
diabetic rats
oxidative stress
cell death
drug induced
endothelial cells
mental health
endoplasmic reticulum stress
signaling pathway
stress induced
pi k akt