Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome.
Serhan YılmazFilipa Blasco Tavares Pereira LopesDaniela SchlatzerRihua WangXin QiMehmet KoyutürkMark R ChancePublished in: bioRxiv : the preprint server for biology (2023)
This study investigates dysregulation of phospho-proteome in an Alzheimer's disease (AD) mouse model, identifying consistent phosphorylation of established AD biomarkers APOE and GFAP, along with novel candidate biomarkers BIG3, CLCN6, and STX7. In addition, the study observes significant PDK1 dysregulation at 9 months, particularly in females. AD-Xplorer, our interactive tool for exploring temporal and sex-linked phosphorylation changes, protein expression, kinase activities, and pathway enrichment, empowers researchers to gain deeper insights into AD mechanisms and uncover novel biomarkers and therapeutic targets.