High-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China.
Ting-Yao MaJun WuShi-Zhi HeXue-Lian WangGuo-Liang YangShu-Jing ZhangJin ZhouYi-Ming DingLi-Feng LiHong-Fei LiuLan-Lan XuanXiao-Hong ChenPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
This study represents the largest single-center cohort of HGT cases to our knowledge, highlighting its frequent occurrence in the sinonasal and lacrimal glands and association with poorer outcomes. The findings support classifying HGT in ACC as Grade 4, reflecting its severity.